TRANSLATIONAL PHYSIOLOGY Acute Lung Injury Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury
نویسندگان
چکیده
Russell P. Bowler, Beth Duda, Edward D. Chan, Jan J. Enghild, Lorraine B. Ware, Michael A. Matthay, and Mark W. Duncan Department of Medicine, National Jewish Medical and Research Center, Denver 80206; Biochemical Mass Spectrometry Facility, University of Colorado Health Sciences Center, Denver, Colorado 80262; Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of California, San Francisco, California 94143; and Department of Molecular and Structural Biology, Århus University, 8000 Århus C, Denmark
منابع مشابه
Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury.
Proteomics is the large-scale analysis of protein profiles. This approach has not yet been reported in the study of acute lung injury (ALI). This study details protein profiles in plasma and pulmonary edema fluid (EF) from 16 ALI patients and plasma and bronchoalveolar lavage fluid (BALF) from 12 normal subjects. More than 300 distinct protein spots were evident in the EF and BALF of both norma...
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The alveolar fibrinolytic system is altered in acute lung injury (ALI). Levels of the fibrinolytic protease inhibitor, plasminogen activator inhibitor-1 (PAI-1), are too low in bronchoalveolar lavage to address its prognostic significance. This study was performed to assess whether PAI-1 antigen in undiluted pulmonary edema fluid levels can identify patients with ALI and predict their outcome. ...
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Acute lung injury (ALI) is characterized by pulmonary edema and acute inflammation leading to pulmonary dysfunction and potentially death. Early medical intervention may ameliorate the severity of ALI, but unfortunately, there are no reliable biomarkers for early diagnosis. We screened for biomarkers in a mouse model of ALI. In this model, inhalation of S. aureus enterotoxin A causes increased ...
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تاریخ انتشار 2004